Cetrizet D Overdosage

Symptoms and Treatment For Overdosage: Cetirizine Hydrochloride: Drowsiness can be a symptom of overdosage, occurring from administration of 50 mg of Cetirizine dihydrochloride as a single dose. In the case of massive overdosage, gastric lavage should be performed together with the usual supportive measures. To date, there is no specific antidote. Apart from the usual supportive measures, all vital parameters have to be monitored regularly.
Pseudoephedrine Hydrochloride: Symptoms of overdosage include irritability, restless, tremor, convulsions, palpitations, hypertension, difficulty in micturition, tachycardia, arrhythmia, signs of CNS depression (sedation, apnea, unconsciousness, cyanosis and cardiovascular collapse) or stimulation (insomnia, hallucination, tremor, seizures) which can be fatal.
Treatment preferably in a hospital setting, should be symptomatic and supportive, taking into account any concomitantly ingested medication. Necessary steps should be taken to maintain the support respiration and control convulsions. Gastric lavage should be performed if indicated. After vomiting, the drug still remaining in the stomach can be absorbed using a suspension of charcoal in water. Apart from the usual supportive measures, all vital parameters have to be monitored regularly. There are no known antidotes. Catheterisation of the bladder may be necessary. If desired, the elimination of pseudoephedrine can be accelerated by acid diuresis or by dialysis. Sympathomimetic amines should not be used.
Hypertension can be controlled with alpha-blockers and tachycardia with beta-blockers. Seizures can be treated with 10 mg of IV diazepam or 0.5 mg/kg of diazepam given rectally in the case of children.